Exploring the Protective Effect of Ascorbic Acid and Aqueous Extract of Spirulina platensis on Methotrexate-Induced Lipid Peroxidation

Authors

Chandana Sengupta Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India

Kunal Roy Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, Indi

Supratim Ray Division of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737 136, India

Abstract:

This study was designed to explore the protective effects of ascorbic acid and water extract of Spirulina platensis (blue green algae) on methotrexate-induced lipid peroxidation using goat liver as the lipid source. This in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates. The study reveals the lipid peroxidation induction capacity of methotrexate, the anti-peroxidative potential of ascorbic acid and aqueous extract of S. platensis on methotrexate-induced lipid peroxidation.

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